Pyridoxamine dihydrochloride

CAS No. 524-36-7

Pyridoxamine dihydrochloride( Pyridorin | Pyridoxylamine Dihydrochloride )

Catalog No. M19616 CAS No. 524-36-7

Pyridoxamine Dihydrochloride is a hydrochloride salt of one form of vitamin B6.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Pyridoxamine dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Pyridoxamine Dihydrochloride is a hydrochloride salt of one form of vitamin B6.
  • Description
    Pyridoxamine Dihydrochloride is a hydrochloride salt of one form of vitamin B6.(In Vitro):Pyridoxylamine (PM), a member of the B6 vitamer family, is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation.(In Vivo):Pyridoxylamine limits the formation of CML and CEL and cross-linking in skin collagen and, ultimately inhibits the development of nephropathy in STZ-diabetic rats. Pyridoxylamine does not appear to function as an antioxidant since it does not prevent lipid peroxidation reactions. At the same time, it does prevent protein modification by products of lipid peroxidation, including inhibiting formation of malondialdehyde and 4-hydroxynonenal adducts on protein in Zucker rats in vivo.
  • In Vitro
    Pyridoxylamine (PM), a member of the B6 vitamer family, is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation.
  • In Vivo
    Pyridoxylamine limits the formation of CML and CEL and cross-linking in skin collagen and, ultimately inhibits the development of nephropathy in STZ-diabetic rats. Pyridoxylamine does not appear to function as an antioxidant since it does not prevent lipid peroxidation reactions. At the same time, it does prevent protein modification by products of lipid peroxidation, including inhibiting formation of malondialdehyde and 4-hydroxynonenal adducts on protein in Zucker rats in vivo.
  • Synonyms
    Pyridorin | Pyridoxylamine Dihydrochloride
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    524-36-7
  • Formula Weight
    241.12
  • Molecular Formula
    C8H14Cl2N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    Cl.Cl.Cc1ncc(CO)c(CN)c1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Adrover M et al. The pyridoxamine action on Amadori compounds: A reexamination of its scavenging capacity and chelating effect. Bioorg Med Chem. 2008 May 15;16(10):5557-69.
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